Orbital and chorioretinal manifestations of Erdheim-Chester disease treated with vemurafenib

Orbital and chorioretinal manifestations of Erdheim-Chester disease treated with vemurafenib

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Purpose: We report a patient with severe multi-organ dysfunction of unknown origin who presented with edgewater shoes bilateral orbital and chorioretinal manifestations that led to the diagnosis of Erdheim-Chester Disease (ECD).Observations: ECD is a rare, histiocytic, proliferative disorder characterized by multi-systemic organ involvement that has historically lacked effective therapy.Our patient underwent genetic testing that was positive for the BRAF V600E mutation; therefore, the patient was treated with vemurafenib.Conclusions and importance: This case demonstrates the rare orbital and intraocular manifestations of ECD and the unfortunate impact of a delayed diagnosis, the importance of early gene therapy testing for management decisions, and the utilization of targeted directed therapy to improve visual outcomes and quality of life.

Keywords: Histiocytosis, Vemurafenib, Orbital, puffy spa headband Chorioretinal, Xanthomatous, Lipogranulomatous, BRAF.